EFIKASI SUPLEMEN BESI-MULTIVITAMIN UNTUK PERBAIKAN STATUS BESI REMAJA WANITA
Article Sidebar
Read Counter : 443
Download : 2440
Main Article Content
Abstract
EFFICACY OF IRON-MULTIVITAMIN SUPPLEMENT FOR IMPROVING THE IRON STATUS OF ADOLESCENT FEMALES
The study was aimed to analyze the efficacy of supplementation iron-multivitamin for improving
the iron status of adolescent females through the double-blind trial. Subjects were 224 of the first
grade university students (IPB) who were randomly allocated to three study groups through a
double blind trial. The first group received only placebo (control group); the second group received
60 mg iron, 250 ug folate (B-F group); the third group received 60 mg iron,800 ug folate, 4200 ug
retinyl acetate, 500 mg vitamin C, and 16.8 ug vitamin B12 (B-MV group). All supplements were
distributed and consumed weekly during 25 weeks. The mean changes in Hb, STfR and SF
among the groups were tested with Ancova and adjusted with BMI; capsule compliance;
food/snack compliance; adequacy of energy, protein, vitamin A, vitamin C, iron; and baseline
value of Hb, STfR, SF. The results showed the demographics and nutritional characteristics of
samples were not significantly different. At the baseline, the mean of haemoglobin
(Hb=126.2±13.1 g/l) and serum ferritin (SF=18.3±15.9 ug/l) were not significantly different among
the three groups (p<0.05). However, the serum transferrin receptor (STfR) was lower in the control
(5.8 ± 3.2 mg/l) than B-F (7.9 ±4.4 mg/l) and B-MV (11.8±5.5 mg/l). After 25 week of
supplementation, the mean change of hemoglobin was not different among the three groups (10.1
g/l; p>0.05). The B-MV group significantly lower decreased in STfR (-4.2 mg/l) and higher
increased in SF (+13.4 ug/l) compared to B-F and control group (p<0.05). Meanwhile, only the
STfR in B-F group (-1.3 ug/l) was significantly lower than control group (p<0.05). This implied the
important of the multi-vitamin to complement the iron supplementation.
Keywords: haemoglobin (Hb), serum transferrin receptor (STfR), serum ferritin (SF), iron status,
iron-multivitamin, iron-folate, adolescent female
Downloads
Article Details
Authors who publish with Gizi Indonesia (Journal of The Indonesian Nutrition Association) agree to the following terms:
- Authors retain copyright and grant Gizi Indonesia (Journal of The Indonesian Nutrition Association) right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to remix, adapt, build upon the work non-commercially with an acknowledgement of the work's authorship and initial publication in Gizi Indonesia (Journal of The Indonesian Nutrition Association).
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).