PENGARUH PEMBERIAN YOGHURT DAN SOYGHURT SINBIOTIK KAYU MANIS (Cinnamomum burmanii) TERHADAP KADAR TRIGLISERIDA DAN TOTAL KOLESTEROL PADA TIKUS PRA-SINDROM METABOLIK

Galuh Dwi Astuti, Deny Yudi Fitranti, Gemala Yudi Anjani, Diana Nur Afifah, Ninik Rustanti
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Abstract

Dyslipidemia is one of the metabolic syndrome risk factors characterized by elevated triglyceride serum and total cholesterol. The yoghurt and soyghurt cinnamon contain lactic acid bacteria, fiber, and bioactive components which play a role to improve triglyceride serum and total cholesterol. The study aimed was to determine the effect of yoghurt and soyghurt symbiotic cinnamon on triglyceride serum and total cholesterol in pre-metabolic syndrome rats. This research was experimental with pre and post control group design. 15 male Sprague Dawley rats that were divided into 5 healthy rats as a negative control group (K) and 10 pre metabolic syndrome rats which were induced with high fat and fructose diet for P1 (yogurt) and P2 (soygurt) which 5 rats per group. The intervention was given for 28 days with a dosage of 0,017ml/BW. P2 (25,50 %) showed reduction of triglyceride higher than P1 (11,34%) and K (12,37%). The total cholesterol reduction in P1 (5,65%) and P2 (7,10%) was lower than K (7,80%). There is no effect of yoghurt and soyghurt synbiotic cinnamon on triglyceride and total cholesterol in pre-metabolic syndrome rats. The other study which has a higher dosage and longer duration in subject with 2 criteria of pre syndrome metabolic is needed.  


ABSTRAK

Dislipidemia merupakan faktor risiko sindrom metabolik ditandai kadar trigliserida dan kolesterol total diatas batas normal. Yoghurt dan soyghurt sinbiotik kayu manis mengandung bakteri asam laktat, serat, serta komponen bioaktif yang dapat memperbaiki kadar trigliserida dan kolesterol total pada pra sindrom metabolik. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian yoghurt dan soyghurt sinbiotik kayu manis terhadap kadar trigliserida dan kolesterol total tikus pra sindrom metabolik. Penelitian ini merupakan true experimental dengan rancangan pre-post test control group. Subjek merupakan 15 tikus Sprague Dawley jantan yang dibagi menjadi 5 tikus normal sebagai kontrol (K) dan 10 tikus pra sindrom metabolik dengan diet tinggi lemak dan fruktosa untuk kelompok P1 (yoghurt) dan P2 (soyghurt) masing-masing 5 tikus. Intervensi yoghurt dan soyghurt diberikan sebanyak 0,017ml/gBB selama 28 hari. Uji beda sebelum dan setelah perlakuan menggunakan Paired t-test atau Wilcoxon. Uji perbedaan antar kelompok menggunakan uji One-Way ANOVA atau Kruskal Wallis. Tidak terdapat penurunan kolesterol total dan trigliserida secara signifikan pada masing-masing kelompok (p>0.05). Penurunan kadar trigliserida pada P2 (25,50%) lebih tinggi daripada K (12,37%) dan P1 (11,34%). Penurunan kadar kolesterol total pada P1 (5,65%) dan P2 (7,10%) lebih rendah daripada K (7,80%). Tidak terdapat pengaruh pemberian yoghurt maupun soyghurt sinbiotik kayu manis terhadap penurunan serum trigliserida dan kolesterol total. Diperlukan penelitian pada kondisi pra sindrom metabolik dengan dua kriteria yang sama, dengan dosis yang lebih tinggi atau durasi yang lebih lama.

 

 


Keywords

yoghurt; soyghurt; cinnamon; triglyceride; total cholesterol; yoghurt; soyghurt; kayu manis; trigliserida; kolesterol total

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