EFEK STATUS TIROKSINEMIA MATERNALTERHADAP TONUS DAN REFLEK BAYI: Studi kohor di daerah endemik deficiency iodium

Abstract

THE EFFECT MATERNAL THYROXINEMIA TO MUSCLE TONES AND REFLEXES OF THE NEW BORN: A Cohort study in endemic iodine deficiency

Studies have shown that iodine deficiency during pregnancy has adverse effects on brain
development of the new born and some period thereafter. However, study on the effect of
thyroxinemia during trimester II to muscle tones and primitive reflexes of the infant in human is
scarce. The objective of the study is to determine the association of the thyroxinemia during second
trimester of pregnancy on neuropsychomotor development of new born. Enrollment of participants,
namely pregnant mothers start in trimester II and measured periodically every month until delivered.
The mothers were examined their health. Neurological examination of new born was also conducted
every month until 24 months old. The study revealed that maternal thyroxinemia during trimester II
significantly associated with muscle tones and primitive reflexes of new born (OR: 5.61 (2,32-13.52)
p=0,000), however maternal TSH, EIU and Hb did not show the relationship. The neonatal TSH and
maternal goiter showed the relationship significantly OR: 2,25 (1,12-4,56) p=0,025 and OR 2,84 (1,56-5,20) p=0,001 respectively, but not for reflex of leg abduction dan foot dorsilation of the new born.
The effect seem to continue along with the increasing infant’s age.

Keywords: maternal thyroxinemia, primitive reflex, TSH, UIE, Hb, Odd Ratio